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Contact allergy to acrylates/methacrylates in the acrylate and nail acrylics series in southern Sweden: simultaneous positive patch test reaction patterns and possible screening allergens
Author(s) -
TeikJin Goon Anthony,
Bruze Magnus,
Zimerson Erik,
Goh CheeLeok,
Isaksson Marléne
Publication year - 2007
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.2007.01151.x
Subject(s) - acrylate , patch test , contact allergy , allergy , nail (fastener) , dermatology , methacrylate , allergic contact dermatitis , contact dermatitis , patch testing , medicine , polymer chemistry , materials science , composite material , immunology , polymerization , copolymer , polymer , metallurgy
In a recent study we showed that all our dental personnel/patients were detected with 2‐hydroxyethyl methacrylate (2‐HEMA) and 2,2‐bis[4‐(2‐hydroxy‐3‐methacryloxypropoxy)phenyl]propane (bis‐GMA). We studied 90 patients tested to the acrylate and nail acrylics series at our department over a 10 year period to see whether screening allergens could be found. Patch testing with an acrylate and nail acrylics series was performed. Among the 10 acrylate/methacrylate‐allergic occupational dermatitis patients tested to the acrylate series, the most common allergens were triethyleneglycol diacrylate (TREGDA, 8), diethyleneglycol diacrylate (5), and 1,4‐butanediol diacrylate (BUDA, 5). All 10 of these patients would have been picked up by a short screening series combining TREGDA, 2‐hydroxypropyl methacrylate (2‐HPMA), and BUDA or 1,6‐hexanediol diacrylate (HDDA). Among the 14 acrylate/methacrylate‐allergic nail patients, the most common allergens were ethylene glycol dimethacrylate (EGDMA, 11), 2‐HEMA, (9), and triethyleneglycol dimethacrylate (9). Screening for 3 allergens i.e. 2‐HEMA plus EGDMA plus TREGDA, would have detected all 14 nail patients. A short screening series combining 2‐HEMA, EGDMA, TREGDA, 2‐HPMA, bis‐GMA, and BUDA or HDDA would have picked up all our past study patients (dental, industrial, and nail) with suspected allergy to acrylate/methacrylate allergens.