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Tixocortol pivalate: what is the right concentration?
Author(s) -
Kalavala Manjunatha,
Statham Barry N.,
Green Cathy M.,
King Clodagh,
Ormerod Anthony D.,
Sansom Jane,
English John S. C.,
Wilkinson Mark S.,
Horne Helen,
Gawkrodger David
Publication year - 2007
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.2007.01136.x
Subject(s) - patch test , hydrocortisone acetate , statistical significance , significant difference , patch testing , medicine , allergy , contact dermatitis , allergic contact dermatitis , contact allergy , dermatology , gastroenterology , hydrocortisone , surgery , immunology
Tixocortol pivalate (TP) is a good marker for hydrocortisone allergy. The concentration of TP to be included in the standard series for patch testing has been the subject of debate. The objective of this study was to investigate the right concentration of TP to be included in the standard series for patch testing. 3747 consecutive patients with dermatitis were patch tested simultaneously with TP 1% and 0.1% in petrolatum at 9 centres in the UK from August 2004 to December 2005. Statistical analysis of the results was performed using S tatistica , version 6 software. 41 patients had positive reactions of current or past relevance. 20 were positive for both concentrations, 13 positive only for TP 1% concentration, and 8 positive only for 0.1% concentration. Statistical analysis, using a two‐tailed difference in proportions test, did not show a significant difference between the 2 concentrations ( P = 0.21). There was no statistically significant difference between the 2 concentrations of TP. The number of allergens that can be included in the standard series is limited for practical considerations. When testing for screening purposes, TP 1% is recommended.