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Methyl esterification of 15‐hydroperoxyabietic acid does not affect the patch‐test result in colophonium allergic patients
Author(s) -
Karlberg AnnTherese,
BråredChristensson Johanna,
Börje Anna,
Harambasic Elma,
Matura Mihàly
Publication year - 2007
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.2006.01037.x
Subject(s) - rosin , abietic acid , patch test , allergen , chemistry , patch testing , abietane , allergic contact dermatitis , resin acid , contact dermatitis , allergy , organic chemistry , medicine , diterpene , immunology
Colophonium (gum rosin) consists of numerous compounds. We have previously shown that abietic acid ( Fig. 1), the major compound in gum rosin, is oxidized to strong contact allergens at air exposure (1). The most potent allergen identified is 15‐hydroperoxyabietic acid (15‐HPA, Fig. 1), which was isolated as its methyl ester ( Fig. 1) and used for patch testing (2, 3). The aim of this study was to confirm the previous postulate that methyl esterification of the carboxyl group in 15‐HPA does not affect the allergenic activity. 1(a) Abietic acid, (b) 15‐hydroperoxyabietic acid (15‐HPA), (c) methyl ester of 15‐HPA.