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Frequency of immediate reactions to the European standard series
Author(s) -
Katsarou A.,
Armenaka M.,
Ale I.,
Koufou V.,
Kalogeromitros D.
Publication year - 1999
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1999.tb06161.x
Subject(s) - paraben , patch test , skin reaction , contact dermatitis , allergen , contact allergy , chemistry , european standard , dermatology , allergy , medicine , organic chemistry , immunology , preservative , architectural engineering , engineering
Immediate contact reactions (contact urticaria) can occur after skin contact with a wide range of substances. We studied the incidence of immediate contact reactions (wheal andare) to the European standard series allergens in 664 patients. Patch tests wererst examined at 30 min for immediate patch test (IPT) reactions, and again at D2 and D4 for delayed patch test (DPT) reactions. Almost all the allergens of the European standard series caused IPT reactions. IPT reactions were most commonly seen with Myroxylon Pereirae (balsam of Peru) (113 reactions), fragrance mix (112 reactions), paraben mix (30 reactions) and clioquinol (13 reactions); these reactions were followed by DPT reactions to the same substance in 13.4%, 8.8%, 10% and 7.7%, respectively. For certain substances, patients with (+) IPT reactions had a signicantly higher incidence of DPT reactions to the same allergen, as compared to patients with (–) IPT reactions (fragrance compounds p < 0.001, formaldehyde p < 0.005, thiuram mix p < 0.01, paraben mix p < 0.05). Thus, perhaps the mechanisms involved in IPT reactions are not the same for all substances. At least for certain substances, an IPT reaction may be related to the development of a DPT reaction.