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Assessment of budesonide patch tests
Author(s) -
Bjarnason Bolli,
Flosadoattir Ellen,
Fischer Torkel
Publication year - 1999
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1999.tb06132.x
Subject(s) - budesonide , patch test , medicine , patch testing , corticosteroid , contact dermatitis , surgery , allergy , immunology
Patch‐test technique for budesonide needs improvement. 20 subjects with positive or questionable patch‐test responses to budesonide were retested for 3 to 96 h (4 days [D]) with polyester patches coated with budesonide in serial doses (150 to 0.074 μ g/cm 2 ). Multiple readings were taken visually and with a laser Doppler perfusion imaging technique up to 264 h (day [D]11). Additionally, all subjects were tested with 0.1% budesonide in petrolatum in Finn Chambers® for 48 h (2D) with readings taken at 72 (D3), 96 (D4) and 168 h (D7). Different dose levels and application times affected unpredictably highest assessments of reactions. No clear suppression of reactivity was observed at high doses. Time points of highest assessments of reactions varied between subjects but were generally the same for each subject with both reading methods regardless of dose levels or application times. Positive and negative subjects during the study were easily distinguished with all serial doses, regardless of assessment technique. At 2.0 μ g/cm 2 , the lowest dose level tested on all subjects, longer applications than 24 h (1D) were required to detect all positive subjects. 48‐h (2‐D) applications required 2 readings, optimally at 96 (D4) and 216 h (D9). The only test technique with Finn Chambers® used here did not make such distinction possible.