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Putative skin‐protective formulations in preventing and/or inhibiting experimentally‐produced irritant and allergic contact dermatitis
Author(s) -
Zhai Hongbo,
Willard Paul,
Maibach Howard I.
Publication year - 1999
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1999.tb06128.x
Subject(s) - irritation , allergic contact dermatitis , irritant contact dermatitis , chemistry , wax , skin irritation , contact dermatitis , hand dermatitis , dermatology , alcohol , allergy , pharmacology , medicine , organic chemistry , immunology
The effectiveness of skin protective formulations was evaluated in a previously‐described in vivo human model. All formulations failed to inhibit ammonium hydroxide and urea irritation. Only parafn wax in cetyl alcohol statistically ( p < 0.01) reduced Rhus allergic contact dermatitis. 3 commercial formulations markedly ( p < 0.001) suppressed sodium lauryl sulfate irritation. Parafn wax in cetyl alcohol was quantitatively the most effective formulation. These results suggest that some formulations may provide protective effects against certain, but not all, irritants or allergens.