Premium
Comparison between 2 test models in evaluating the effect of a moisturizer on irritated human skin
Author(s) -
Held Elisabeth,
Agner Tove
Publication year - 1999
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1999.tb06060.x
Subject(s) - moisturizer , transepidermal water loss , forearm , medicine , irritation , skin irritation , dermatology , surgery , chemistry , pathology , stratum corneum , food science , immunology
The purpose of the present study was to compare 2 experimental models of moisturizer efficacy on the recovery of irritated skin on the hands and the volar forearms. 12 healthy volunteers had their hands immersed in sodium lauryl sulfate (SLS) 10 min 2° daily for 2 days, and at the same time the volunteers had patch tests with SLS (0.125%, 0.25% and 0.5%) applied on their forearms for 24 h. After irritation of the skin, the volunteers had a moisturizer applied on one arm/hand 3° daily for the following 9 days. The other arm/hand served as untreated control. Evaluation was done on days (D) 1, 3, 5, 8 and 12 by transepidermal water loss, electrical capacitance, laser Doppler flowmetry and DermaSpectrometry. Both models were found useful, and the moisturizer was found to accelerate regeneration of the skin barrier function in both the hands (D8, p <0.05) and the volar forearms (0.5% SLS, D5 and D8, p <0.01). When the forearm model is used in the present set‐up, a relatively high concentration of SLS (<0.25%) should be used and evaluation measurements are best performed on D5‐D8. The forearm model proved reliable and easy to handle and we suggest that this model is used in future studies on moisturizer evaluation.