Premium
Squamometry: an evaluation method for a barrier protectant (tannic acid)
Author(s) -
Sfflmizu Tomokazu,
Maibach Howard I.
Publication year - 1999
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1999.tb06031.x
Subject(s) - tannic acid , distilled water , chemistry , chromatography , sodium , organic chemistry
Squamometry for evaluating skin barrier substances is described. Forearms of 8 volunteers were dosed with 0, 0.25, 0.5, and 1% sodium lauryl sulfate (SLS) in distilled water (semi‐open method) for 24 h, to skin pretreated with distilled water and 5% tannic acid, a model barrier protectant. Squamometric evaluation indicated the skin damage increased with SLS concentration in a dose‐dependent manner, and that tannic acid reduced the damage ( p <0.01). The results suggest that squamometry may be a useful method for determining efficacy of skin barrier substances.