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Prevention of nickel‐induced allergic contact reactions with pentoxifylline
Author(s) -
Saricaoglu H.,
Tunali S.,
Bulbul E.,
White I. R.,
Palali Z.
Publication year - 1998
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1998.tb05917.x
Subject(s) - pentoxifylline , sensitization , patch test , contact dermatitis , medicine , pharmacology , allergic contact dermatitis , immunology , allergy , chemistry
In this study, we investigated the effect of pentoxifylline, an inhibitor of TNF‐α, on the contact sensitivity response induced by nickel. For induction, open epicutaneous sensitization by NiSO 4 . 6H 2 O (25% aq.) solution was applied on the backs of 38 albino guinea pigs 5 days a week for 4 weeks. NaCl (0.9%) solution was applied epicutaneously to 10 albino guinea pigs as a control group. 19 were sensitized by nickel and developed positive patch test reactions. Patch tests were repeated after 10 of the sensitized pigs were given pentoxifylline 20 mg/kg/day orally. At the end of this study, only 2 positive patch test reactions were observed in the pentoxifylline‐treated group, while 7/9 of the untreated guinea pigs developed positive reactions. These results suggest that pentoxifylline inhibits the contact sensitivity response induced by nickel only during drug administration.