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Objective assessment of nickel sulfate patch test reactions with laser Doppler perfusion imaging
Author(s) -
Bjarnason Bolli,
Fischer Torkel
Publication year - 1998
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1998.tb05858.x
Subject(s) - laser doppler velocimetry , perfusion , patch test , nuclear medicine , blood flow , contact dermatitis , laser , medicine , biomedical engineering , optics , radiology , allergy , physics , immunology
The laser Doppler perfusion scanning technique was used to assess the superficial blood flow of nickel sulfate hexahydrate patch test reactions. There was good agreement between laser Doppler and visual assessments when the highest assessment values of reactions were studied. Earlier detection of reactions was possible with the laser technique. There was great inter‐individual variance in perfusion between identically tested patients. 4 patients were visually negative when a TRUE Test TM patch test dose of 0.20 mg/cm 2 was applied for 48 h and the test area read 4× up to 168 h. These 4 showed a dose‐related increase in perfusion and visually positive reactions using longer application times. The instrument allowed a dose reduction not possible for visual assessments. Reading transparent patches in contact with the skin through transparent semi‐occlusive plastic foil or through windows in the tape strip over the patches, allowed us to detect perfusion at 48 h, where a longer application would have been needed using tape and visual assessments.