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The effect of patch duration on the elicitation of para‐phenylenediamine contact allergy
Author(s) -
McFadden J. P.,
Wakelin S. H.,
Holloway D. B.,
Basketter D. A.
Publication year - 1998
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1998.tb05837.x
Subject(s) - p phenylenediamine , medicine , patch test , allergy , hair dyes , contact allergy , allergic contact dermatitis , patch testing , dermatology , contact dermatitis , immunology , chemistry , organic chemistry , dyeing
To study the length of exposure time required to elicit para‐phenylenediamine (PPD) allergic reactions, patients known to be allergic to PPD were recruited and patch tested. A group of 7 patients were patch tested with 1% PPD in pet. for 15 min, 30 min and for 120 min. The remaining 9 patients were patch tested with 1%, 0.3%, 0.1% and 0.01% PPD for 15 min, 30 min and for 120 min each. With exposure for 120 min, 11 of 16 subjects reacted to 1% PPD and 2 of 9 reacted to 0.01%. With exposure of 15 min, 6 of 16 reacted to 1% PPD and 0 of 9 reacted to 0.01% PPD. This study showed marked inter‐individual variability in eliciting a reaction to the PPD molecule on patch testing, with regard to both the exposure time and the concentration required.