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Nickel content of standard patch test materials
Author(s) -
Nakada Tokio,
Hostynek Jurij J.,
Maibach Howard I.
Publication year - 1998
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1998.tb05835.x
Subject(s) - patch test , nickel , patch testing , test (biology) , allergic contact dermatitis , contact dermatitis , medicine , dermatology , materials science , metallurgy , allergy , immunology , biology , paleontology
The nickel sulfate content in standard patch test materials currently used in the US, Europe and Japan was determined by inductively‐coupled plasma atomic emission spectroscopy, a state‐of‐the‐art microanalytical method which allows nickel detection to levels of 7 ppb (μg/l). In 2 materials with a nominal concentration of 5% nickel sulfate hexahydrate in pet., the range (calculated averages of triplicate analyses of 3 different batches) was from 4.72 to 4.87% and 4.97 to 5.39%, respectively. In 1 material with a 2.5% nominal concentration in pet., the values ranged from 2.41 to 2.48%. The range seen in a 5% NiSO 4 hexahydrate aq. material was 4.95 to 5.03%. The range for 2.5% NiSO 4 anh. in pet. was 2.39 to 2.49%. This data suggest a significant improvement in quality control compared to our previously published data.