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Contact sensitivity and systemic reaction to pseudoephedrine and lignocaine
Author(s) -
Downs Anthony M. R.,
Lear John T.,
Wallington Tim B.,
Sansom Jane E.
Publication year - 1998
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1998.tb05811.x
Subject(s) - medicine , drug eruption , dermatology , erythema , adverse effect , nasal decongestant , anesthesia , pseudoephedrine , allergic contact dermatitis , patch test , hypersensitivity reaction , drug reaction , allergy , drug , pharmacology , immunology , ephedrine
There are 4 cases reported of generalized erythema, joint swelling, tachycardia and rigors with oral pseudoeph‐edrine (1–3), many cases of non‐purpuric fixed drug eruption from oral pseudoephedrine (3); and 2 cases of positive patch tests to pseudoephedrine, 1 after a fixed drug eruption (3), and 1 after a generalized eczema (4). There are reports of adverse reactions to lignocaine fol‐lowing its use as a subcutaneous injection, deep dental infiltration, and as a topical application (5). Adverse re‐actions to lignocaine are quite common, but immune pathology cannot usually be demonstrated. Adverse re‐actions that are mediated by the immune system are generally of the immediate type (Type I), whilst delayed allergy is rare (6).