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Adverse skin reactions to vitamin K 1 : report of 2 cases
Author(s) -
Balato N.,
Cuccurullo F. M.,
Patruno C.,
Ayala F.
Publication year - 1998
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1998.tb05774.x
Subject(s) - menadione , vitamin k , clotting factor , vitamin , medicine , dermatology , adverse effect , gastroenterology , oxidative stress
Vitamin K is essential to the biosynthesis of prothrombin and other clotting factors (VII, IX and X), and is mostly used for the prophylaxis of bleeding disorders, mainly in patients with hepatic disfunction (1). 4 different pharmacological forms exist: the natural form K1 (phytomenadione); K 2 (menaquinone), which is derived from intestinal bacterial action; K 3 (menadione); and K 4 (menadiol). The latter 2 are synthetic products. In Italy, only vitamin K1 is marketed (2). Adverse cutaneous reactions to vitamin K are rare; 2 are mainly reported: an erythematous plaque (3, 4) or pseudo‐scleroderma (5) at the injection site. Contact dermatitis and localized urticarial lesions have also been described (2).