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Comparison of simultaneous patch testing with parthenolide and sesquiterpene lactone mix
Author(s) -
Orion E.,
Paulsen E.,
Andersen K. E.,
Menne T.
Publication year - 1998
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1998.tb05708.x
Subject(s) - parthenolide , sesquiterpene lactone , sesquiterpene , lactone , allergic contact dermatitis , patch test , medicine , allergy , traditional medicine , dermatology , chemistry , stereochemistry , immunology , apoptosis , biochemistry
Several studies have pointed out that the sesquiterpene lactone (SL) mix is a safe, though inadequate, screen for Compositae allergy. To test the usefulness of the sesquiterpene lactone parthenolide as a supplementary Compositae screening test to the mix, both were included in the standard series in 2 Danish dermatology departments. Among 2244 patients tested, 46 (2%) were positive to SL mix and 73–75% of these were positive to parthenolide. The results demonstrate that parthenolide is not suitable as a supplementary screening agent to SL mix, but may be a fairly good screen on its own if the mix is not available.