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Mechanism of allergic contact dermatitis from propacetamol: sensitization to activated N,N ‐diethylglycine
Author(s) -
Berl Valerie,
Barbaud Annick,
Lepoittevin JeanPierre
Publication year - 1998
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1998.tb05704.x
Subject(s) - sensitization , allergic contact dermatitis , contact dermatitis , acetaminophen , antipyretic , allergy , medicine , dermatology , chemistry , pharmacology , immunology , analgesic
In order to confirm the mechanism of skin sensitization to propacetamol, a pro‐drug of acetaminophen, 3 patients with allergic contact dermatitis from propacetamol were patch tested with N,N ‐diethylglycine phenyl ester, an activated form of N,N ‐diethylglycine. Positive patch tests were observed in all the patients at 10% in pet., while 20 control patients remained negative. This strongly suggests that propacetamol is acting as an activated form of N,N ‐diethylglycine, transferring this part of the molecule to nucleophilic residues of proteins. This also explains why reactions to acetaminophen have never been observed in patients sensitized to propacetamol.