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Pretreatment of skin with a Ginkgo biloba extract/sodium carboxymethyl‐β‐1,3‐glucan formulation appears to inhibit the elicitation of allergic contact dermatitis in man
Author(s) -
Castelli D.,
Colin L.,
Camel E.,
Ries G.
Publication year - 1998
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1998.tb05676.x
Subject(s) - ginkgo biloba , medicine , allergic contact dermatitis , placebo , contact dermatitis , dermatology , ginkgoales , allergen , patch test , allergy , traditional medicine , pharmacology , chemistry , immunology , pharmacognosy , in vitro , biological activity , pathology , biochemistry , alternative medicine
The clinical efficiency of mitigating contact dermatitis with a Ginkgo biloba extract and carboxyme‐thyl‐β‐1,3‐glucan formulation was investigated in a double‐blind versus placebo study using 22 subjects (Caucasian women aged 22–55 years) with allergic contact dermatitis from various substances in the European standard series. The formulation was applied to intact skin 2× a day for 2 weeks (“in use” application) prior to a single application of a selected contact allergen under a Finn Chamber for 24 h. Readings were carried out in a blind study by a dermatologist 2 and 3 days after patch removal. Representative photographs were taken of treated, placebo and untreated test areas. 68.2% of the panelists showed significantly reduced skin reactivity ( p = 0.037*) on the treated site 2 days after patch removal, versus untreated and/or placebo sites. This finding indicates that the Ginkgo biloba /carboxymethyl‐β‐1,3‐glucan formulation can mitigate against allergic contact dermatitis.