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Extraction of mercaptobenzothiazole compounds from rubber products
Author(s) -
Hansson C.,
Bergendorff O.,
Ezzelarab M.,
Sterner O.
Publication year - 1997
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1997.tb00269.x
Subject(s) - acetone , chemistry , extraction (chemistry) , solvent , natural rubber , benzothiazole , organic chemistry , ether , chromatography
At evaluation of contact dermatitis caused by solid material, patch testing is usually performed with the material as such and with extracts of it. In this study, optimization of the extraction technique monitored by quantitative HPLC analysis of the extracted haptens is described for mercaptobenzothiazole derivatives. Several solvents with different properties are included. Acetone has traditionally been a solvent widely used for the extraction of organic haptens from solid products. However, acetone and other ketones are not inert solvents. The rubber accelerators 2‐(4‐morpholi‐nyl mercapto) benzothiazole (MMBT) and N‐cydoliexyl‐2‐benzoihiazyl sulfenamide (CBS) react with acetone, yielding 2 new compounds, which were isolated and characterised by NMR and MS. For the extraction of solid rubber products, methyl tert‐butyl ether (MTBE) was found to be a more suitable solvent which is unreactive to most common haptens.