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The major allergen of Dendropanax trifidus Makino
Author(s) -
Oka Keiko,
Saio Fumio,
Yasuhara Ta ashi,
Sugimoo Akiko
Publication year - 1997
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1997.tb00212.x
Subject(s) - araliaceae , allergen , hedera helix , traditional medicine , botany , allergy , biology , chemistry , medicine , immunology , ginseng , alternative medicine , pathology
Dendropanax trifidus Makino (family Araliaceae, syn. Gilibertia trifida Makino) has been reported as causing allergic contact dermatitis in Japan. To identify the major allergen, fractionated extracts of fresh leaves of Dendropanax trifida were patch tested on 2 patients with hypersensitivity to the plant. Cis‐9,17‐octiidecadiene‐12,14‐diyne‐1,16‐diol ( I ), an analog of falcarinol, was identified as an active component. 18 normal control subjects were patch tested with the leaf of Dendropanax trifidus and I diluted to 0.05% in pet. 4 of them showed active sensitization to the leaf of Dendropanax trifidus and I. Our results suggest that I is the major allergen of Dendropanax trifidus and is a strong sensitizer. The results of patch testing on patients and control subjects with the leaves of Fatsia japonica Decne. et Planch, and Hedera helix L. which also belong to the Araliaceae family, and urushiol are also shown.