Premium
Influence of temperature on irritation in the hand/forearm immersion test
Author(s) -
Clarys P.,
Manou I.,
Barel A. O.
Publication year - 1997
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1997.tb00209.x
Subject(s) - transepidermal water loss , stratum corneum , irritation , chemistry , dry skin , immersion (mathematics) , penetration (warfare) , skin irritation , forearm , irritant contact dermatitis , dermatology , chromatography , surgery , allergy , contact dermatitis , medicine , pathology , mathematics , operations research , pure mathematics , engineering , immunology
As indicated by in vitro experiments the penetration of irritants through the skin is significantly influenced by the temperature of the solution. In vivo experiments, demonstrated equally a significant influence of temperature in surfactant‐induced skin irritation. In order to evaluate the irritant potential of detergent solutions under normal user conditions. we used the hand/forearm immersion test. We compared to detergents with different anionic character in a repetitive immersion protocol (30 min immersion on 4 consecutive days). The solutions were tested at 2 temperatures (37°C and 40°C). The irritation was quantified by assessment of the stratum corneum barrier function (transepidermal water loss), skin redness ( a * colour parameter) and skin dryness (capacitance method). Both detergents affected the integrity of the skin in a significant way. The anionic content as well as the temperature of the solutions were found to be determinative for the irritant potential, with a stronger response for higher anionic content and temperature, respectively.