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The influence of hard water (calcium) and surfactants on irritant contact dermatitis
Author(s) -
Warren Raphael,
Ertel Ketth D.,
Bartolo Robert G.,
Levine Mark J.,
Bryant Paula B.,
Wong Louis F.
Publication year - 1996
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1996.tb02414.x
Subject(s) - irritant contact dermatitis , irritation , hard water , contact dermatitis , pulmonary surfactant , chemistry , dryness , erythema , transepidermal water loss , skin irritation , dermatology , allergy , surgery , medicine , organic chemistry , stratum corneum , biochemistry , pathology , immunology
Although the induction of irritant contact dermatitis has been extensively studied for surfactants, the role of the environmental factor water hardness (i.e., calcium content) on the induction process has not received attention. Our objective was 10 investigate differences in surfactant‐induced irritant skin reactions from cumulative exposure to 3 different personal cleansing agents and determine whether the irritation potential can be affected by the hardness of the water. 2 commonly used exaggerated washing procedures were variously employed lo evaluate representative sodium‐soap, triethanolamine‐soap, or synthetic detergent cleansers under conditions where the water hardness varied from 0‐grain to 11‐grain (gr). Subjects were clinically evaluated for skin dryness, skin redness, and instrumentally for hydration. Soap binding to skin was quantified using Fourier transform infrared reflectance spectroscopy. Using the more mild wash procedure, skin sites treated under conditions of hard. 11 gr water, were significantly drier, had more erythema, and were less hydrated than corresponding sites treated with deionized 0 gr water. All 3 surfactant cleansers behaved similarly. We also found the hardness of the rinse water to be the more significant factor, versus that of the wash water. Effect of water hardness on soap binding to skin revealed a similar outcome. Under a more exaggerated wash condition the relationship between water hardness and irritation broke down.