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Chlorothalonil, a possible cause of erythema dyschromicum perstans (ashy dermatitis) *
Author(s) -
Penagos Homero,
Jimenez Victor,
Fallas Victor,
O'Malley Michael,
Maibach Howard I.
Publication year - 1996
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1996.tb02360.x
Subject(s) - dermatology , chlorothalonil , medicine , erythema , contact dermatitis , patch test , pesticide , allergy , immunology , biology , agronomy
We studied 39 patients with erythema‐dyschromicum‐perstans‐like dermatitis seen at Changuinola Hospital in Panama. They were compared with 41 controls. The 2 groups were native field workers of the banana plantations exposed to many pesticides. In 34 patients, there was a positive patch test reaction to 2,4,5,6‐l, 3‐tetrachloroisophlhalonilnitrile (chlorothalonil. TCPN) 0.001% in acetone. In 39 cases, biopsies showed a lichenoid tissue reaction compatible with a chronic pigmented dermatitis or erythema‐dyschromicum‐perstans‐like dermatitis, Chlorothalonil is possibly the cause of the pigmented dermatitis observed in the 39 banana farm workers studied. Until additional studies are carried out. We consider this a possible rather than definite cause‐and‐effect relationship.