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Sodium lauryl sulfate effect on the density of epidermal Langerhans cells.
Author(s) -
Mikulowska Anna,
Andersson Anders
Publication year - 1996
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1996.tb02240.x
Subject(s) - chemistry , contact dermatitis , sodium , sulfate , irritant contact dermatitis , dermatology , langerhans cell , forearm , significant difference , epidermis (zoology) , irritation , chromatography , immunology , medicine , allergy , pathology , anatomy , organic chemistry , antigen
The effect of different test models for sodium lauryl sulfate (SLS)‐induced irritant contact dermatitis on epidermal Langerhans cells (LC) numbers was examined. Finn Chambers, 8 and 12 mm, containing 15 and 34 or 50 μl, respectively. of l% aq. solution of SLS were applied to human forearm skin for 48h as single or repeated application. The results showed a clear difference between the effects with the 2 chamber Sizes. The effect of the 8‐mm chambers could result in increased, unchanged or decreased LC numbers, while 12‐mm chambers always produced a decrease. These results seem to explain, at least partly, the discrepant results reported from various laboratories.