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Sensitization studies with mometasone furoate, tixocortol pivalate, and budesonide in the guinea pig
Author(s) -
Bruze Magnus,
Björkner Bert,
DoomsGoossens An
Publication year - 1996
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1996.tb02166.x
Subject(s) - mometasone furoate , budesonide , corticosteroid , medicine , sensitization , guinea pig , dermatology , pharmacology , chemistry , endocrinology , immunology
Mometasone furoate is a new corticosteroid, synthesized to have an improved ratio of anti‐inflammatory potential to adverse effects. The guinea pig maximization test was used to determine the sensitizing capacity of mometasone furoate, and also to investigate cross‐reaction patterns in animals sensitized to tixocortol pivalate and budesonide, respectively. Tixocortol pivalate was shown to be a sensitizer in the guinea pig, but cross‐reactions to other tested corticosteroids wore not observed. Furthermore, no sensitizing capacity could be demonstrated for budesonide or mometasone furoate.