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Variation in response of human skin to irritant challenge
Author(s) -
Judge M. R.,
Griffiths H. A.,
Basketter D. A.,
Whitte I. R.,
Rycroft R. J. G.,
McFadden J. P
Publication year - 1996
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1996.tb02141.x
Subject(s) - irritant contact dermatitis , human skin , irritation , dermatology , skin test , in vivo , medicine , contact dermatitis , allergy , immunology , pathology , biology , tuberculosis , genetics , microbiology and biotechnology
A major obstacle to the establishment of a protocol for in vivo irritant skin testing in humans is the apparent variability of responses between individuals. This study of the threshold response of normal human skin to a standard irritant (sodium lauryl sulfate 0.3–10%), in a group of 22 subjects, revealed a marked interindividual variation in their threshold reaction. The results demonstrate that this phenomenon does exist and that it will have to be allowed for in future human irritant test systems or assays.