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Eczematous‐like drug eruption induced by synergistins
Author(s) -
Michel M.,
Dompmartin A.,
Szczurko C.,
Casttel B.,
Moreau A.,
Leroy D.
Publication year - 1996
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1996.tb02135.x
Subject(s) - virginiamycin , medicine , dermatology , ingestion , sensitization , hypersensitivity reaction , atopy , drug eruption , allergy , antibiotics , drug , contact dermatitis , anaphylaxis , immunology , pharmacology , chemistry , biochemistry
The authors report 4 cases of eczematous‐1ike drug eruption after oral ingestion of pristinamycin (3 cases) and virginiamycin (1 case). The lesions occurred after contact sensitization with topical virginiamycin. The clinical symptoms appeared a few hours after ingestion: a generalized maculopapular eruption, sometimes with general symptoms of anaphylactic reaction. Eczema appeared again on initial areas of contact dermatitis. There is a common allergenic group between these 2 antibiotics, which is a macrocyclic lactone. Physiopathology of this drug eruption is not clear: allergic reaction of the delayed type or anaphylactic reaction. Patients allergic to virginianmycin should be strongly cautioned against oral pristinamycin.