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Oral lichenoid lesions, mercury hypersensitivity and combined hypersensitivity to mercury and other metals: histologically‐proven reproduction of the reaction by patch testing with metal salts
Author(s) -
Koch Partick,
Bahmer Frienrich A.
Publication year - 1995
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1995.tb02046.x
Subject(s) - patch test , mercury (programming language) , oral mucosa , dermatology , amalgam (chemistry) , medicine , sensitization , allergic contact dermatitis , contact allergy , dentistry , patch testing , hypersensitivity reaction , allergy , oral lichen planus , contact dermatitis , chemistry , pathology , immunology , electrode , computer science , programming language
We report 11 patients seen between 1991 and 1994 with oral lichenoid lesion(OLL). In 10 cases, there was contact with dental amalgam fillings, and in patient no. 10 with both amalgam restorations and a gold crown. The last patient had, in addition to her OLL, lichen planus of the skin and genital mucosa. In 5 cases, combined sensitization to mercury and other metal salts, particularly gold sodium thiosulfate (GST) and palladium chloride (PDC), was observed. In 10 patients, the lesions considerably improved or totally cleared within 1 to 9 months of replacement of restoration materials. Histological examination of biopsies from the test sites of amalgam, mercuric chloride, GST and PDC, taken 10 or 17 days, after application of patch tests, showed lichenoid changes in 7 patients with at least 1 of the allergens. At least 2 patients had inflammatory lesions of the oral mucosa related to both amalgam and gold restorations, combined sensitization to inorganic and organic mercury derivatives. GST and, in 1 case, PDC, a “dental restoration metal intolerance syndrome” is proposed.