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The chemistry of contact allergy: why is a molecule allergenic?
Author(s) -
Basketter David,
DoomsGoossens An,
Karlberg AnnTherese,
Lepoittevin JeanPierre
Publication year - 1995
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1995.tb00748.x
Subject(s) - allergy , contact allergy , allergic contact dermatitis , allergen , chemistry , contact dermatitis , molecule , dermatology , organic chemistry , immunology , medicine
This review concentrates on some specific aspects of the chemistry of allergic contact dermatitis. The way low molecular weight chemicals react with skin proteins to form complete antigens will be discussed and the development of molecular modelling techniques to analyse molecular recognition presented. Subsequently, how knowledge of the chemical structure can be used to estimate the allergenic activity of a molecule will be considered. This aspect includes work with qualitative and quantitative structure‐activity relationships (SAR) in the field of contact allergy.