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Patch testing with preservatives at St John's from 1982 to 1993
Author(s) -
Jacobs M.C.,
White I. R.,
Rycroft R. J. G.,
Taub N.
Publication year - 1995
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1995.tb00476.x
Subject(s) - preservative , formaldehyde , chemistry , allergy , urea , diol , organic chemistry , medicine , immunology
We have reviewed our patch test results for preservative allergy from 1982 to W3. 8 preservatives were included: formaldehyde. 2‐bromo‐2‐nitropropane‐1,3‐diol (Bronopol™), quatenium‐15 (Dowicil 200™). Imidazolidinyl urea (Germall 115™). diazolidinyl urea (Germall 11™) and 1,2‐dibromo‐2,4‐dicyanpbutane (one of the constituents of Euxyl K 400™). Whereas the allergy rate to formaldehyde is quite stable, there is a slight increase in the imidazolidinyl urea allergy rate to formaldehyde is quite stable, there is a slight increase in the imidazolidinyl urea allergy rate. Quaternium‐15's rate a rapid rise seems to have stabilized. Although very important constituents of cosmetics, preservatives not only induce allergies on the face but also on the hands, and, as expected, the allergy rate in men and women generally differs. Among the 5 formaldehyde‐releasers, there are some favoured simultaneous reactions quaternium ‐15 and formaldehyde, and diazolidinyl urea or imidazolidinyl urea. Coccomitant reactions between 1‐brome‐2‐nitropropane‐1,3‐diol and formaldehyde are not common, and those between 2‐brome‐2‐nitropropane‐1,3‐diol and disazolidynl urea or imidazolidinyl urea very uncommon. Concomitant reactions between imidazolidinyl urea, diazolidinyl urea, and formaldehyde are not very common. This supports the hypothesis that allergic reactions to the Germalls are directed toward the initial molecule rather than to formaldehyde.