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Butenylbithiophene, α‐terthienyl and hydroxytremetone as contact allergens in cultivars of marigold ( Tagetes sp.)
Author(s) -
Hausen Björn M.,
Helmke Burkhard
Publication year - 1995
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1995.tb00444.x
Subject(s) - tagetes , phototoxicity , asteraceae , cultivar , chemistry , traditional medicine , ornamental plant , botany , biology , medicine , biochemistry , in vitro
Ornamental cultivars of Tagetes sp., commonly named marigold, are one of the presently most popular pot, and garden plants. Sensitizing experiments in guinea pigs with short ether extract and isolated compound‐ repealed the presence of 3 constituents that must be considered as contact allergens. They were identified as 5‐(3‐buten‐1‐ynyl)‐2.2′‐bithiophene, α‐terthienyl and hydroxytremetone. In sensitized animals, butenylbithiophene showed moderate to strong Sensitizing potency while α terthienyl was less strong and hydroxytremetone weak. The results demonstrate, for the first time, that at least some of the thiophenes abundantly occurring in many species of the Composite family possess not only phototoxic activity but also sensitizing properties.