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Nickel/magnesium interactions in nickel‐sensitive patients
Author(s) -
Santucci B.,
Cannistraci C.,
Cristaudo A.,
Picardo M.
Publication year - 1995
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1995.tb00442.x
Subject(s) - nickel , chemistry , magnesium , chloride , patch test , penetration (warfare) , sulfate , nuclear chemistry , immunology , allergy , organic chemistry , medicine , operations research , engineering
Experimentally demonstrated interactions between Ni 2+ and Mg 2+ were examined in human beings. 110 subjects patch‐test‐positive to 10μl aq. NiSO 4 0.1 M were solutions into groups of 30.50 and 30 people. Each subgroup was tested to 10μl NiSO 4 0.1 M solution as a control and to mixed solutions containing NiSO 4 0.1 M together with. respectively MgSO 4 0.1 and 0.3. 0.3 and 0.5 and 0.5 and 1 M. On increasing the applied concentrations of MgSO 4 , the % of patients with reduced or suppressed nickel reactions, with 1 exception, proportionally increased. The exception concerned testing with 0.5 M. where a paradoxically exacerbating increase in nickel reactions was seen in a majority of nickel‐sensitive subjects. MgCl 2 aq. at 0.3. 0.5 and 1 M concentrations was not able to reduce the cutaneous patch test positive reactions to NiCl 2 0.1 M in 25 sensitive patients. On increasing the applied concentrations of MgCl 2 both the number and intensity of patch test reactions to NiCl 2 proportionally increased. A supposed role of the sulfate and chloride counterions in the penetration of nickel was examined in 30 NiSO 4 5% patch‐test‐positive testing to 10μl of aq, NisO 4 0.1 M. NiCl 2 0.1 M. NiSO 4 0.1 M + MgCl 2 0.3 M, NiCl 2 0.1 M + MgSO 4 0.3 Na 2 SO 4 0.3. NiSO 4 0.1 M + Na 2 SO 4 0.3 M, NiSO 4 0.1 M + Na 2 SO 4 0.3 NiCl 2 0.1 M+ NACl 0.3 M the findings suggest that the addition OF sulfate or chloride to nickel could determine the formation of different Ni complexes directed toward different targets, one Mg 2+ ‐dependent, the other Mg 2+ ‐independent.