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The sodium lauryl sulfate model: an overview
Author(s) -
Lee Cheol Heon,
Maibach Howard I.
Publication year - 1995
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1995.tb00438.x
Subject(s) - irritation , irritant contact dermatitis , dosing , contact dermatitis , eye irritation , sulfate , dermatology , chemistry , medicine , pharmacology , allergy , immunology , organic chemistry
Irritant contact dermatitis is a complex entity with several clinical forms (acute, cumulative, etc.) and multiple mechanisms. Sodium lauryl sulfate (SLS), the most widely utilized model for studying acute and cumulative irritation, has proved highly practical and informative for such studies. This article summarizes several decade of investigation, and provides details of dosing, application method (closed versus open), and biologic endpoints (visual grading, transpidermal water loss) that may be utilized in future studies.