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Diazolidinyl urea: incidence of sensitivity, patterns of cross‐reactivity and clinical relevance
Author(s) -
Hectorne Kathleen J.,
Fransway Anthony F.
Publication year - 1994
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1994.tb00722.x
Subject(s) - sensitization , dermatology , allergic contact dermatitis , medicine , cosmetics , formaldehyde , contact dermatitis , biocide , allergy , preservative , contact allergy , incidence (geometry) , reactivity (psychology) , immunology , chemistry , organic chemistry , pathology , physics , alternative medicine , optics
Diazolidinyl urea (DIAZ) is a formaldehyde‐releasing preservative used in cosmetics and personal‐care products, which has been identified as a sensitizing agent in contact dermatitis. To determine whether DIAZ sensitization is secondary to formaldehyde release or due to its own allergenic properties, we reviewed 708 consecutive patch tests of patients with various dermatologic complaints. Profiles of the 58 individuals (8%) with DIAZ sensitivity were analyzed with respect to sex, age, exposures, and chronicity of dermatitis. Significant coexistent biocide reactivity was demonstrated for DIAZ and formaldehyde (81%); 12% reacted to DIAZ alone. We conclude that the primary mode of sensitization of DIAZ is via formaldehyde release and that independent contact allergy is less frequent.