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Interaction of metals in nickel‐sensitive patients
Author(s) -
Santucci B.,
Cannistraci C.,
Cristaudo A.,
Picardo M.
Publication year - 1993
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1993.tb03559.x
Subject(s) - nickel , chemistry , nuclear chemistry , medicinal chemistry , inorganic chemistry , organic chemistry
Nickel (Ni) dermatitis is, thought to involve the formation of complexes between Ni ions and suitable proteins. 4 groups of 30 subjects who gave positive patch test responses to NiSO 4 2.9% aq. were each retested to 1 of 4 different solutions containing equimolar (0.1 M) amounts of NiSO 4 plus MgSO 4 . NiSO 4 plus CuSO 4 , NiSO 4 plus ZnSO 4 . and NiSO 4 plus Li 2 SO 4 , respectively. The results, evaluated at 2 days by visual scoring only, demonstrated that the 4 metals exerted a different influence on the nickel reactions, perhaps interfering with one or more factors affecting the formation of Ni++ complexes.