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In vitro evidence of delayed‐type hypersensitivity to hydrocortisone
Author(s) -
Wilkinson S. M.,
English J. S. C.,
Mattey D. L.
Publication year - 1993
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1993.tb03557.x
Subject(s) - hydrocortisone , corticosteroid , allergy , medicine , peripheral blood mononuclear cell , delayed hypersensitivity , in vitro , hypersensitivity reaction , immunology , chemistry , immune system , biochemistry
Hypersensitivity to topical hydrocortisone is becoming increasingly recognized. We present further evidence that this is mediated via a delayed‐type hypersensitivity reaction. A hydrocortisone: albumin complex was able to induce a proliferative response in the peripheral blood mononuclear cells of patients allergic to hydrocortisone. Protein binding of hydrocortisone or a degradation product may be important in the development of corticosteroid allergy.