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Efficacy of skin barrier creams
Author(s) -
Frosch Peter J.,
SchulzeDirks Astried,
Hoffmann Monika,
Axthelm Inge
Publication year - 1993
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1993.tb03486.x
Subject(s) - irritation , transepidermal water loss , erythema , skin irritation , chemistry , emulsion , dermatology , irritant contact dermatitis , guinea pig , contact dermatitis , medicine , allergy , stratum corneum , organic chemistry , pathology , immunology , endocrinology
A popular “skin protector” consisting of an emulsion‐like foam of lipophilic and hydrophilic substances (Marly skin®) was evaluated in a previously described repetitive irritation guinea pig model, The product failed to inhibit the irritation due 10 sodium lauryl sulphate and toluene. In striking contrast to the recommended use, the irritant response of sodium hydroxide was aggravated, as demonstrated by significant differences for all test parameters (clinical score for erythema and scaling, transepidermal water loss, blood How volume). The results show that protection against chemical irritants may be quite specific and that some formulations may actually be harmful.