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A standard protocol for phototoxicity testing
Author(s) -
Nilsson R.,
Maurer T.,
Redmond N.
Publication year - 1993
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1993.tb03433.x
Subject(s) - phototoxicity , reproducibility , protocol (science) , medicine , acridine , dermatology , chemistry , pathology , chromatography , in vitro , biochemistry , alternative medicine , organic chemistry
Based on experience accumulated in a number of laboratories, a standardized protocol for phototoxicity testing in experimental animals by the dermal route is presented. By conducting a limited interlaboratory study, demonstrating a high degree of consistency using 8‐methoxypsoralen {8‐MOP) and acridine, the sensitivity and reproducibility of the proposed methodology is demonstrated. Important aspects of performing phototoxicity testing are discussed.