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The sensitizing potency of Euxyl® K 400 and its components 1,2‐dibromo‐2,4‐dicyanobutane and 2‐phenoxyethanol
Author(s) -
Hausen B. M.
Publication year - 1993
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1993.tb03376.x
Subject(s) - potency , adjuvant , allergic contact dermatitis , allergy , medicine , pharmacology , stereochemistry , chemistry , dermatology , immunology , biochemistry , in vitro
Using a modified FCA (Freund's complete adjuvant) procedure, the sensitizing capacity of Euxyl K® 400 and its ingredients, 1,2‐dibromo‐2.4‐dicyanobutane and 2‐phenoxyethanol, has been studied in guinea pigs. The experiments demonstrate that a distinct but weak sensitizing potency exists for Euxyl® K 400 and dibromodicyanobutane. Phenoxyethanol remained almost negative. These results are in good accordance with the low number of cases of allergic contact dermatitis due to Euxyl® K 400 and dibromodicyanobutane described since their introduction on the market. Cases of phenoxyethanol contact allergy have been published hitherto only 4× in the medical literature.