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Allergic contact reaction to dexpanthenol: lymphocyte transformation test and evidence for microsomal‐dependent metabolism of the allergen
Author(s) -
Hahn Carolyn,
Rritzsche Stefani,
Fritzsche Rainier,
Schneider Rosemarie,
Merk Hans F.
Publication year - 1993
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1993.tb03346.x
Subject(s) - microsome , allergic contact dermatitis , sensitization , allergen , chemistry , immunology , pharmacology , cytochrome p450 , medicine , allergy , metabolism , enzyme , biochemistry
In a patient with contact dermatitis, dexpanthenol was found to be the causative allergen. There was a positive reaction to dexpanthenol on patch testing. Controls did not show any positive reactions to dexpanthenol on patch testing. Additionally, an LTT was performed, Alter pre‐incubation with dexpanthenoi‐modified microsomes. we observed an increase in lymphocyte proliferation to dexpamhenol, in comparison to dexpamhenol without microsomes. suggesting that microsomes metabolism plays a role in the pathogenesis of dexpanthenol sensitization, because microsomes are known to posses drug metabolizing enzymes such as cytochrome P450.