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Irritant cutaneous reactions to N‐methyl‐2‐pyrrolidone (NMP)
Author(s) -
Leira Hakos L.,
Tiltnse Arne,
Svendsen Kristin,
Vetlesen Lars
Publication year - 1992
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1992.tb05243.x
Subject(s) - irritant contact dermatitis , contact dermatitis , dermatology , irritation , allergic contact dermatitis , medicine , solvent , chemistry , organic chemistry , allergy , immunology
Several workers in small electrotechnical company in Norway experienced irritant reactions of the skin ‐after a few days of working with the solvent N‐methyl2‐pyrrolidone (NMP). Due to concern about the health risk of commonly‐used organic solvents, the company had chosen to use NMP when one of its products had to be treated with a solvent. After 2 days of work with NMP, 10 of the 12 involved workers displayed acute irritant contact dermatitis of the hands. According to published reports. NMP is not considered to be particularly irritant to the skin. The Safety Data Sheet of a Norwegian sales firm contained no information on cutaneous hazards, but the Safety Data Sheet of an American producer of NMP stated the risk of severe dermatitis upon prolonged contact. NMP seems to more irritant to the human skin than reported thus far.