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Allergic contact dermatitis from the preservative 1,2‐benzisothiazolin‐3‐one (1,2‐BIT; Proxel®): a case report, its prevalence in those occupationally at risk and in the general dermatological population, and its relationship to allergy to its analogue Kathon® CG
Author(s) -
Damstra Robert J.,
Vloten Willem A.,
Ginkel Cornelis J. W.
Publication year - 1992
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1992.tb05218.x
Subject(s) - patch test , allergic contact dermatitis , medicine , preservative , bit (key) , allergy , dermatology , patch testing , contact dermatitis , contact allergy , population , european standard , food science , environmental health , immunology , chemistry , architectural engineering , computer security , computer science , engineering
Occupational contact allergy to 1,2‐benzisothiazolin‐3‐one (1,2‐BIT, proxel®) is analysed. This compound is widely used in industry as a preservative in water based solutions such as pastes, paints and cutting oils. The optimal concentration for patch testing proved to 0.4 g/1 (0.04%) in water. In 4 out of 17 patients (23%) at occupational risk (painters paper‐hangers), contact allergy to 1,2‐BIT was found. Of 556 consecutive dermatological patients without clear occupational risk, 10 (1.8%) showed positive patch tests to 1,2‐BIT; in 3 patients, 1,2‐BIT Gontact allergy was related to domestic paper‐hanging. Although the chemical structure of l,2‐BIT 1 shows some analogy with the preservative Kathon® CG. true cross‐sensitivity was found to be unlikely