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Electrical impedance applied to non‐invasive detection of irritation in skin
Author(s) -
Ollmar Stig,
Emtestam Lennart
Publication year - 1992
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1992.tb05195.x
Subject(s) - irritation , skin irritation , electrical impedance , eye irritation , focused impedance measurement , biomedical engineering , materials science , chemistry , medicine , dermatology , immunology , electrical engineering , engineering
Healthy volunteers were subjected to irritation by sodium lauryl sulphate at concentrations in the range 0.002% to 5.0% applied in Finn Chambers for 24 h. Test sites were visually assessed 1 h and 24 h niter cessation of exposure. At the same limes electrical impedance was measured with a new impedance device which allows non‐invasive local measurements to a controlled depth. Close agreement between concentration and an irritation index calculated from electrical impedance parameters was found over the whole concentration range for most test persons‐ At concentrations below 0.2%, visual scores were zero. These results suggest that electrical impedance can ht; used as an objective tool to record irritation, and furl her that electrical impedance might be a more sensitive method than the commonly used visual readings.