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Role of keratinocytes in allergic contact dermatitis
Author(s) -
Barker Jonathan N. W. A.
Publication year - 1992
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1992.tb00283.x
Subject(s) - allergic contact dermatitis , contact dermatitis , immunology , chemotaxis , cytokine , in vitro , in vivo , keratinocyte , patch test , allergen , chemistry , immune system , allergy , microbiology and biotechnology , biology , receptor , biochemistry
Although once thought to play a purely structural role, there is increasing evidence that keratinocytes are actively involved in epidermal immune responses, including allergic contact dermatitis (ACD). In vitro studies demonstrate that both urushiol and nickel sulphate induce cytokine production in cultured keratinocytes including molecules responsible for endothelial cell activation and lymphocyte chemotaxis and adhesion, In vivo, these same molecules are expressed in experimentally induced patch test reactions to a variety of allergens, Furthermore, such expression precedes the onset of the inflammatory phase of ACD. Taken together, these studies suggest a role complementary to that of Langerhans cells for keratinocytes in the initiation and propagation of ACD