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Human irritant response to qualities and concentrations of cocoamidopropylbetaines: a possible model of paradoxical irritant response
Author(s) -
Vilaplana J.,
Mascaró J. M.,
Trullas G.,
Coll J.,
Romaguera C.,
Zemba C.,
Peleiero C.
Publication year - 1992
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1992.tb00120.x
Subject(s) - transepidermal water loss , irritant contact dermatitis , chemistry , cosmetics , laser doppler velocimetry , micelle , critical micelle concentration , contact dermatitis , stratum corneum , dermatology , chromatography , allergy , medicine , organic chemistry , pathology , immunology , blood flow , aqueous solution
Cocoamidopropylbetatnes arc surfactants frequently used in cosmetics. We have evaluated the irritant capacity of 3 different qualities of cocoamidopropylbetaine, using the following method; patch tests have been carried out with 5 different dilutions in 67 patients and the results read at 2 days by noninvasive methods (direct visualization, transepidermal water loss (TEWL). laser Doppler flowmetry (LDF)). The results with the 3 methods were concordant. However, the results with the different concentrations were paradoxical, as irritancy did not increase at higher concentrations We have tried to explain this by the fact that these substances contain by‐products (free amidoamine and sodium monochloroacetate), the concentrations tested all being above the critical micelle concentration and therefore containing both micelles and monomer. Finally, we believe that noninvasive methods such as TEWL and LDF could be of treat use in the evaluation of irritant contact dermatitis