Premium
Sequential order of skin responses to surfactants during a soap chamber test *
Author(s) -
Simon F. Anthony,
Rhein Linda D.,
Grove Gary L.,
Wojtkowski Janet M.,
Cagan Robert H.,
Scala Diana D.
Publication year - 1991
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1991.tb01852.x
Subject(s) - stratum corneum , erythema , irritation , dermatology , pulmonary surfactant , chemistry , desquamation , skin irritation , dermis , transepidermal water loss , medicine , pathology , immunology , biochemistry
Differences in the response of distinct layers of the skin to surfactants were probed using a modification of the Frosch and Kligman soap chamber test. Soap and other surfactant‐containing cleansers corneum is readily damaged even by a mild insult when no erythema is induced. A more severe treatment, such as 24‐h exposure to a 5% solution, induced the maximal level of barrier damage but a submaximal level of erythema. Even 2 days of exposure to 5% soap does not elicit a maximal erythema response. These results suggest that the stratum corneum is more readily damaged than the dermis. Which is not unexpected because the stratum corneum is the readily damaged than the surfactant and skin. Furthermore, this study indicates that for discriminating among mild products, when a small degree of irritation is induced. The most effective measure is stratum corneum damage assessed by evaporimetry. However, for evaluating more irritating products, erythema is probably the more discriminating evaluation technique.