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Assessment of the relative skin sensitizing potency of 3 biocides using the murine local lymph node assay
Author(s) -
Botham Philip A.,
Hilton Jennifer,
Evans Christopher D.,
Lees David,
Hall Tony J.
Publication year - 1991
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1991.tb01823.x
Subject(s) - local lymph node assay , potency , biocide , lymph node , chemistry , lymph , pharmacology , toxicology , medicine , immunology , in vitro , pathology , biochemistry , biology , organic chemistry
The relative skin‐sensitizing potency of 3 biocides, 5‐chloro‐2‐methyl‐4‐isothiazolin. one the major active ingredient in Kathon® CG). 1,2‐benzisothiazolin‐3‐one and 2‐ethyl‐4,trimethylene‐4‐is isothiazolin‐3‐one, was assessed using the murine local lymph node assay. Potency was ranked according to the lowest dose of material which, following epicutoneous exposure Induced u significant proliferation of lymphocytes in the draining lymph nodes, The results showed that 5‐ehtorn‐2‐melhyl‐4‐isothiazolin‐3‐one was able to induce proliferative activity significantly lower dose levels than the other 2 biocides and that it may therefore be a more potent skin sensitizer.