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Euxyl K 400: a new sensitizer in cosmetics
Author(s) -
Tosti Antonella,
Guerra Liliana,
Bardazzi Federico,
Gasparri Franco
Publication year - 1991
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1991.tb01794.x
Subject(s) - cosmetics , patch test , lotion , medicine , dermatology , allergic contact dermatitis , contact dermatitis , contact allergy , allergy , sensitization , patch testing , preservative , traditional medicine , food science , chemistry , pathology , immunology
Euxyl K 400 is a preservative for cosmetics and toiletries containing 2 active ingredients, 1,2‐dibronio‐2,4‐dtcyynobutitn and 2‐phenoxyethanol. 2057 consecutive patients with contact dermatitis were patch tested with Euxyl K 400 2.5% pet. and ethanol. A positive patch test occurred in 24 patients (1.2%). The source of sensitization was traced in N patients to their cosmetics. Both leave‐on and rinse‐off products were responsible, Further patch tests with Euxyl K 400 0.5% pet. and phenoxyethanol 5% pet. were performed in 11 patients. A positive patch test to phenoxyethanol was detected in 1 of them. Only 3 patients showed to mild reaction to Euxyl K. 400 0.5% A provocative use test with a lotion preserved with Euxyl K 400 0.1% was positive in 5 of these 11 patients. Patients with Euxyl K 400 sensitivity showed a high prevalence of positive patch tests to other common ingredients of cosmetics. Since the use of Euxyl K 400 in cosmetic products is rapidly increasing, it should he included in the patch test series for patients with suspected cosmetic allergy.