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Cross‐reactivity between sensitivity to thimerosal and photosensitivity to piroxicam in guinea pigs
Author(s) -
Kitamura Kazuko,
Osawa Junko,
Ikezawa Zenro,
Nakajima Hiroshi
Publication year - 1991
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1991.tb01769.x
Subject(s) - thimerosal , photosensitivity , piroxicam , dermatology , medicine , contact dermatitis , cross reactivity , allergic contact dermatitis , reactivity (psychology) , allergy , cross reactions , chemistry , immunology , materials science , pathology , alternative medicine , optoelectronics , antibody
Piroxicam (PXM) is a nansteroidal anti‐inflammatory drug which may induce a photosensitive eruption shortly after administration. We examined whether animals sensitized to thimerosal developed a photosensitivity to PXM. Male Hartley strain guinea pigs were sensitized to thimerosal, thiosalicylate and PXM separately. The open patch test was used lo evaluate sensitization to each drug and cross‐reactions between the drugs. Animals sensitized to thimerosal exhibited positive patch test thimerosal to thiosalicylate and positive path test reactions to PXM. Both those sensitized to thiosalicylate and to PXM showed positive patch test reactions to PXM. This study demonstrated that thimerosal induces cross‐sensitivity to PXM in vivo and that the common active components among these compounds may be thiosalicylate.