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Occupational allergic contact dermatitis caused by nitroglycerin
Author(s) -
Kanerva Lasse,
Laine Risto,
Jolanki Riitta,
Tarvainen Kyllikki,
Estlander Tuula,
Helander Inkeri
Publication year - 1991
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1991.tb01750.x
Subject(s) - nitroglycerin (drug) , allergic contact dermatitis , medicine , isosorbide dinitrate , contact dermatitis , patch testing , angina , irritant contact dermatitis , allergy , anesthesia , dermatology , immunology , myocardial infarction
Irritant contact dermatitis caused by occupational contact with nitroglycerin has been known since the end of the last century, Nitroglycerin is an allergen, and the transdermal drug deliver; systems for nitroglycerin recently used to treat angina pectoris have sensitized 4 patients with allergic contact dermatitis caused by nitroglycerin from explosives are described, and I patient who was sensitized by transdermal nitroplaster. On patch testing dynamite and/or the explosive components nitroglycerin, ethylene glycol dinitrate and dinitrotoluene gave allergic reactions. The following concentration and vehicles are suggested for patch testing: nitroglycerin 0.5–2% pet., dinitrotoluene and ethylene glycol dinitrate 0.1–0.5% pet., Persons exposed to nitroglycerin at work should try to avoid skin contact by using protective gloves. It is advisable that those who have become allergic to nitroglycerin should wear disposable protective gloves when handling explosives.