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Screening for corticosteroid contact sensitivity
Author(s) -
Lauerma A. I.
Publication year - 1991
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1991.tb01664.x
Subject(s) - hydrocortisone , corticosteroid , medicine , chemistry , endocrinology , dermatology
3 corticosteroids have so far been tried as markers for corticosteroid contact sensitivity; hydrocortisone, tixocortol privalate and hydrocortisone‐17‐butyrate. The present study compared these steroids for screening in addition to a standard patch test series. Of 727 patients, 28 (3.9%) reacted to tixocortol pivalate and 10 (1.4%) to hydrocortisone‐17‐butyrate; hydrocortisone gave an allergic reaction in 2 of 521 (0.4%) to hydrocortisone‐17‐butyrate; hydrocortisone gave an allergic in Finland, caused allergic reactions which could possibly be cross‐reactions to hydrocortisone. In contrast to previously published data, frequent cross‐reactions occurred with hydrocortisone‐17‐butyrate and tixocortol pivalate. All allergic reactions to other corticosteroids found by testing with tixocortol pivalate concurred with reactions to hydrocortisone‐17‐butyrate. The study suggests that the most effective choice for routine testing for corticosteroid contact sensitivity would be both tixocortol pivalate and hydrocortisone‐17‐butyrate.